Endocrine Abstracts

Introduction: The indications for anti-PD1 agents have expanded considerably in recent years, particularly for the treatment of melanoma, lung cancer and kidney cancer.Hypophysitis is a rare complication of anti-PD1 agents (< 1%) often with an atypical presentation, characterized by a later onset and a less symptomatic presentation.Case report: A 60-year-old woman was diagnosed with a clear cell renal carcinoma, treated with le...

Introduction: Alemtuzumab, a humanized monoclonal antibody against CD52, is effective in the treatment of early relapsing-remitting multiple sclerosis (MS). Thyroid side-effects such as Graves’ disease have been already described. We describe one case of unusual subacute thyroiditis after alemtuzumab treatment.Clinical case: A 38 year-old-female was treated by alemtuzumab for 2 years. She was referred for hyperthyroidism with 10 kg weight loss, diar...

Primary hyperparathyroidism is the third most common endocrine disorder, caused, in the majority of cases, by a single parathyroid adenoma and rarely by multigland adenoma or parathyroid carcinoma. Giant parathyroid adenomas, defined as larger than 3 g, represent an uncommon cause of primary hyperparathyroidism, with only a few cases described in the literature. We present the case of a 47 years old female who presented with a significant, unpainful, left cervical mass associa...

Pheochromocytoma is a rare tumor of the adrenal medulla, responsible for excessive secretion of catecholamines. Symptoms include the classic triad: headache, palpitations and sweating, usually accompanied by hypertension. We report the case of a pheochromocytoma diagnosed following an episode of testicular necrosis. A 72-year-old patient with history of psoriasis and prostate resection underwent emergency surgery for increased testicular pain suspicious of testicular tumor. Pa...

Oncocytic adrenocortical neoplasms (OAN) were first described by Kakimoto et al. in 1986. Since then, only 160 cases have been reported in the literature. There are 3 categories of OANs: pure oncocytic, mixed oncocytic and ordinary adrenocortical with focal oncocytic changes. Although the majority of OANs are considered benign tumors, certain OANs may present similar characteristics to adrenocortical carcinoma, correct histological caractherisation is therefore crucia...